This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. While several transcript variants have been described, the biological validity of only one has been determined.
LPHN2; latrophilin 2; latrophilin 1 , LPHH1; latrophilin-2; KIAA0786; LEC1; CIRL-2; lectomedin-1; latrophilin 1; latrophilin homolog 1; latrophilin homolog 2 (cow); calcium-independent alpha-latrotoxin receptor 2; CL2; CIRL2; LPHH1