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lphn1

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Official Full Name
latrophilin 1
Background
This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane. Alternative splicing results in multiple variants encoding distinct isoforms.
Synonyms
LPHN1; latrophilin 1; latrophilin-1; CIRL1; KIAA0821; LEC2; Calcium independent alpha latrotoxin receptor 1; CL1; Latrophilin1; Lectomedin 2; LPHN 1; CIRL-1; lectomedin-2; calcium-independent alpha-latrotoxin receptor 1