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llgl2

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Official Full Name
lethal giant larvae homolog 2 (Drosophila)
Background
The lethal (2) giant larvae protein of Drosophila plays a role in asymmetric cell division, epithelial cell polarity, and cell migration. This human gene encodes a protein similar to lethal (2) giant larvae of Drosophila. In fly, the proteins ability to localize cell fate determinants is regulated by the atypical protein kinase C (aPKC). In human, this protein interacts with aPKC-containing complexes and is cortically localized in mitotic cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
Synonyms
LLGL2; lethal giant larvae homolog 2 (Drosophila); lethal giant larvae (Drosophila) homolog 2; lethal(2) giant larvae protein homolog 2; HGL; human giant larvae homolog; LGL2; cb521; llglh2; sb:cb521; zgc:55895; wu:fc06g08; wu:fl37c09; pen; penner; protein penner