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lims1

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Official Full Name
LIM and senescent cell antigen-like domains 1
Background
The protein encoded by this gene is an adaptor protein which contains five LIM domains, or double zinc fingers. The protein is likely involved in integrin signaling through its LIM domain-mediated interaction with integrin-linked kinase, found in focal adhesion plaques. It is also thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its localization to the periphery of spreading cells also suggests that this protein may play a role in integrin-mediated cell adhesion or spreading. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Synonyms
LIMS1; LIM and senescent cell antigen-like domains 1; PINCH; PINCH1; PINCH-1; LIM and senescent cell antigen-like-containing domain protein 1; renal carcinoma antigen NY-REN-48; particularly interesting new Cys-His protein 1; wu:fc32c03; zgc:112533

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