Official Full Name
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
The protein encoded by this gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family. LIR family members are known to have activating and inibitory functions in leukocytes. Crosslink of this receptor protein on the surface of monocytes has been shown to induce calcium flux and secretion of several proinflammatory cytokines, which suggests the roles of this protein in triggering innate immune responses. This gene is one of the leukocyte receptor genes that form a gene cluster on the chromosomal region 19q13.4. Four alternatively spliced transcript variants encoding distinct isoforms have been described.
LILRA5; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5; LILRB7; leukocyte immunoglobulin-like receptor subfamily A member 5; CD85; CD85f; ILT11; LIR9; CD85 antigen-like family member F; ILT-11; Immunoglobulin like transcript 11 protein; Immunoglobulin-like transcript 11; Leukocyte Ig like receptor 9; Leukocyte immunoglobulin like receptor subfamily A (with TM domain) member 5; Leukocyte immunoglobulin-like receptor 9; Leukocyte immunoglobulin-like receptor subfamily B (with TM and ITIM domains) member 7; LIR-9; LIRA5_HUMAN; leukocyte Ig-like receptor 9; immunoglobulin-like transcript 11 protein; leukocyte immunoglobulin-like receptor subfamily A member 5 soluble; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 7