Official Full Name
leucine zipper, down-regulated in cancer 1
The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.
LDOC1; leucine zipper, down-regulated in cancer 1; BCUR1; protein LDOC1; Mar7; Mart7; Breast cancer up regulated 1; Breast cancer upregulated 1; Gm366; Leucine zipper down regulated in cancer 1; Leucine zipper protein down regulated in cancer cells; RGD1565644; OTTHUMP00000024174; breast cancer, up-regulated 1; leucine zipper protein down-regulated in cancer cells