This gene encodes a cytosolic leucine-tRNA synthetase, a member of the class I aminoacyl-tRNA synthetase family. The encoded enzyme catalyzes the ATP-dependent ligation of L-leucine to tRNA(Leu). It is found in the cytoplasm as part of a multisynthetase complex and interacts with the arginine tRNA synthetase through its C-terminal domain. Alternatively spliced transcript variants of this gene have been found; however, their full-length nature is not known.
LARS; leucyl-tRNA synthetase; leucyl-tRNA synthetase, cytoplasmic; FLJ10595; FLJ21788; HSPC192; LARS1; leucine tRNA ligase 1; cytoplasmic; LEUS; RNTLS; Leucine tRNA ligase; Cytoplasmic leucyl tRNA synthetase; Cytosolic leucyl tRNA synthetase; hr025Cl; HSPC 192; KIAA1352; LARS 1; Leucine translase; Leucyl tRNA synthetase cytoplasmic; LeuRS; LRS; PIG 44; PIG44; Proliferation inducing gene 44; OTTHUMP00000223912; OTTHUMP00000223913; leucine-tRNA ligase; leucine--tRNA ligase; proliferation-inducing gene 44; cytosolic leucyl-tRNA synthetase; cytoplasmic leucyl-tRNA synthetase; leucine tRNA ligase 1, cytoplasmic