The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin is contained primarily in the filiform tongue papilla, among other hair keratins.
KRT84; keratin 84; hHb4; Basic Hair Keratin K84; HB4; KRTHB4; K84; Hb-4; keratin-84; type-II keratin Kb24; type II hair keratin 4; keratin, hair, basic, 4; hard keratin, type II, 4; type II hair keratin Hb4; keratin, type II cuticular Hb4.