This gene encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor that functionally cooperates with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.
KREMEN2; kringle containing transmembrane protein 2; kremen protein 2; KRM2; MGC10791; Dickkopf receptor 2; KREMEN 2; Kremen protein 2 precursor; Kringle containing protein marking the eye and the nose; Kringle domain containing transmembrane protein 2; KRM 2; MGC16709; kringle domain-containing transmembrane protein 2; kringle-containing protein marking the eye and the nose