Kininogens are inhibitors of thiol proteases. HMW Kininogen plays an important role in blood coagulation by helping to position optimally pre-Kallikrein and Factor XI next to Factor XII. HMW Kininogen inhibits the Thrombin- and Plasmin-induced aggregation of thrombocytes; the active peptide Bradykinin that is released from HMW Kininogen shows a variety of physiological effects: influence in smooth muscle contraction, induction of hypotension, natriuresis and diuresis and decrease in blood glucose level. It is also a mediator of inflammation and causes increase in vascular permeability, stimulation of nociceptors release of other mediators of inflammation (e.g. Prostaglandins) and it has a cardioprotective effect (directly via Bradykinin action, indirectly via endothelium-derived relaxing factor action).
HMWK light chain; Kininogen 1; Kininogen 1 light chain; KNG; KNG1; BDK, kininogen , KNG; kininogen-1; alpha 2 thiol proteinase inhibitor; bradykinin; HMWK; fitzgerald factor; high molecular weight kininogen; alpha-2-thiol proteinase inhibitor; williams-Fitzgerald-Flaujeac factor; BDK; fb64g01; wu:fb64g01; zgc:103569