Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.
KLF12; Kruppel-like factor 12; Krueppel-like factor 12; AP 2 repressor; AP 2rep; AP 2rep transcription factor; AP2REP; HSPC122; KLF12 zinc finger transcriptional repressor; AI315654; AP-2rep; B130052C06Rik; D530033K05Rik; OTTHUMP00000018503; 2700063E05Rik; AI225908; AP-2 repressor; AP-2rep transcription factor; Krueppel like factor 12; Transcriptional repressor AP 2rep; transcriptional repressor AP-2rep; AP2REP, AP-2rep, HSPC122