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Official Full Name
kit ligand
Background
Murine SCF or Stem Cell Factor, also known as Kit Ligand, is a 273 amino acid cytokine protein expressed from the Kitl gene located on chromosome 10. After initial synthesis and translocation, the 25 residue signal sequence is cleaved, allowing for the 248 residue SCF to properly fold and mature. If the SCF or Kit Ligand is cleaved again on the C- terminal end at residue 190, then the soluble Kit Ligand is formed. SCF, a non-covalently linked homodimer, is known to stimulate the proliferation of mast cells and is able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Also, SCF serves to mediate cell-cell adhesion and acts synergistically with other cytokines and interleukins.
Synonyms
Clo; Con; Gb; Kitlg; Mgf; SCF; SF; SLF; Sl; contrasted; C-kit ligand; Steel factor; cloud gray; grizzle-belly; hematopoietic growth factor KL; mast cell growth factor; stem cell factor Location: 10 51.4 cM