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kif7

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Official Full Name
kinesin family member 7
Background
This gene encodes a cilia-associated protein belonging to the kinesin family. This protein plays a role in the sonic hedgehog (SHH) signaling pathway through the regulation of GLI transcription factors. It functions as a negative regulator of the SHH pathway by preventing inappropriate activation of GLI2 in the absence of ligand, and as a positive regulator by preventing the processing of GLI3 into its repressor form. Mutations in this gene have been associated with various ciliopathies.
Synonyms
KIF7; kinesin family member 7; kinesin-like protein KIF7; JBTS12; EQYK340; ACLS; HLS2; UNQ340; MGC120653; MGC138476; MGC138478; cos2; costal2; kinesin-like protein costal2