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kiaa0892

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Official Full Name
MAU2 sister chromatid cohesion factor
Background
Scc4 (Mau2) is the metazoan homologue of Scc4 in S. cerevisiae. In yeast, Scc4 binds to Scc2 to form an essential complex that loads cohesion onto chromosomes. Similarly, the Scc4 / Mau2 protein in metazoans plays a significant role in sister chromatid separation and in loading of cohesin onto chromatin. The Scc2-Scc4 complex is tethered to pre-replication complexes through the Cdc7-Drf1 protein kinase DDK.
Synonyms
MAU2; MAU2 sister chromatid cohesion factor; SCC4; MAU2L; mau-2; KIAA0892; MAU2 chromatid cohesion factor homolog; protein MAU-2; sister chromatid cohesion 4; cohesin loading complex subunit SCC4 homolog