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kdelr2

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Official Full Name
KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
Background
Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms
KDELR2; KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; ER lumen protein retaining receptor 2; ELP 1; ERD2.2; (Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 2; ELP1; ERD 2 like protein; ERD2 like protein 1; FLJ45532; KDEL (Lys Asp Glu Leu) endoplasmic reticulum protein retention receptor 2; KDEL endoplasmic reticulum protein retention receptor 2; KDEL receptor 2; KDELR 2; ERD-2-like protein; ERD2-like protein 1; (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2; ELP-1; ER lumen protein-retaining receptor 2