This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins, which belong to the recoverin branch of the EF-hand superfamily. Members of this family are small calcium binding proteins containing EF-hand-like domains. They are integral subunit components of native Kv4 channel complexes that may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. The encoded protein also functions as a calcium-regulated transcriptional repressor, and interacts with presenilins. Alternatively spliced transcript variants encoding different isoforms have been described.
KCNIP3; Kv channel interacting protein 3, calsenilin; calsenilin, presenilin binding protein, EF hand transcription factor , CSEN; calsenilin; DREAM; KCHIP3; DRE-antagonist modulator; kv channel-interacting protein 3; potassium channel interacting protein; potassium channel interacting protein 3; A-type potassium channel modulatory protein 3; calsenilin, presenilin-binding protein, EF hand transcription factor; CSEN; MGC18289; CSEN, DREAM, KCHIP3