Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member includes three distinct isoforms which are encoded by three alternatively spliced transcript variants of this gene. These three isoforms are beta subunits, which form heteromultimeric complex with alpha subunits and modulate the activity of the pore-forming alpha subunits.
KCNAB1; potassium voltage-gated channel, shaker-related subfamily, beta member 1; voltage-gated potassium channel subunit beta-1; AKR6A3; hKvb3; hKvBeta3; KCNA1B; Kvb1.3; K(+) channel subunit beta-1; potassium channel beta 3 chain; potassium channel beta3; potassium channel beta3 subunit; potassium channel shaker chain beta 1a; potassium voltage-gated channel beta subunit; voltage-gated potassium channel beta-1 subunit; KV-BETA-1; hKvb3, AKR6A3, KCNA1B, Kvb1.3, hKvBeta3, KV-BETA-1; putative potassim channel beta-subunit; potassium channel Shaker beta 1 subunit cKvbe; KVBETA1