Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. This gene encodes the p80 subunit. This protein is a member of the AAA family of ATPases. Multiple alternatively spliced variants, encoding the same protein, have been identified.
KATNA1; katanin p60 (ATPase containing) subunit A 1; katanin p60 ATPase-containing subunit A1; EC 18.104.22.168; Katanin p60 ATPase containing subunit A1; Katanin p60 subunit A1; KTNA1_HUMAN; OTTHUMP00000017392; OTTHUMP00000042860; p60 katanin; katanin p60 (ATPase-containing) subunit A 1; zgc:110580; si:dkey-15j16.1