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jmjd2c

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Official Full Name
lysine (K)-specific demethylase 4C
Background
This gene is a member of the Jumonji domain 2 (JMJD2) family and encodes a protein with one JmjC domain, one JmjN domain, two PHD-type zinc fingers, and two Tudor domains. This nuclear protein functions as a trimethylation-specific demethylase, converting specific trimethylated histone residues to the dimethylated form. Chromosomal aberrations and increased transcriptional expression of this gene are associated with esophageal squamous cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Synonyms
KDM4C; lysine (K)-specific demethylase 4C; GASC1; JHDM3C; JMJD2C; TDRD14C; bA146B14.1; lysine-specific demethylase 4C; GASC-1 protein; tudor domain containing 14C; jumonji domain containing 2C; jumonji domain-containing protein 2C; gene amplified in squamous cell carcinoma 1 protein; JmjC domain-containing histone demethylation protein 3C; wu:fd55d07; zgc:153957