Regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of the inositol 1,4,5-trisphosphate 3-kinase is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. It is also a substrate for the cyclic AMP-dependent protein kinase, calcium/calmodulin- dependent protein kinase II, and protein kinase C in vitro.
ITPKA; inositol-trisphosphate 3-kinase A; inositol 1,4,5 trisphosphate 3 kinase A; IP3 3KA; IP3KA; IP3K A; IP3 3-kinase A; insP 3-kinase A; inositol 1,4,5-trisphosphate 3-kinase A; IP3-3KA