Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory;factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region;and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the;IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha;and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced;by viral infection.
IRF8; interferon regulatory factor 8; interferon consensus sequence-binding protein; interferon consensus sequence binding protein 1; Myls; ICSBP; IRF-8; Icsbp1; AI893568; ICSBP1, interferon consensus sequence binding protein 1; IRF 8; H-ICSBP; H-ICSBP, ICSBP, ICSBP1, IRF-8, IRF8; interferon consensus sequence binding protein; zgc:92252; DKEYP-77B5.1