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impdh2

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Official Full Name
IMP (inosine 5'-monophosphate) dehydrogenase 2
Background
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5-monophosphate into xanthine-5-monophosphate, which is then converted into guanosine-5-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation.
Synonyms
IMPDH2; IMP (inosine 5-monophosphate) dehydrogenase 2; inosine-5-monophosphate dehydrogenase 2; EC 1.1.1.205; IMDH2_HUMAN; IMP (inosine monophosphate) dehydrogenase 2; IMP dehydrogenase 2; IMP oxireductase 2; IMPD 2; IMPD2; IMPDH 2; IMPDH II; IMPDH-II; IMPDHII; Inosine 5 monophosphate dehydrogenase 2; inosine 5 phosphate dehydrogenase 2; inosine monophosphate dehydrogenase type II; IMPD2, IMPDH-II; cb635; wu:fb64g02; wu:fc43f09