Interleukins are a group of cytokines that were first seen to be expressed by white blood cells (leukocytes). The term interleukin derives from as a means of communication, and deriving from the fact that many of these proteins are produced by leukocytes and act on leukocytes. The name is something of a relic though (the term was coined by Dr. Paetkau, University of Victoria); it has since been found that interleukins are produced by a wide variety of body cells. The function of the immune system depends in a large part on interleukins, and rare deficiencies of a number of them have been described, all featuring autoimmune diseases or immune deficiency. The majority of interleukins are synthesized by helper CD4+ T lymphocytes, as well as through monocytes, macrophages, and endothelial cells. They promote the development and differentiation of T, B, and hematopoietic cells.
B cell growth factor 1; B cell IgG differentiation factor; B Cell Stimulatory Factor 1; BCGF1; Binetrakin; BSF-1; HCGF; Hodgkin’s Cell Growth Factor; IA Inducing Factor; IGG1 induction factor; IL 4; IL4_HUMAN; Il4e12; Interleukin 4, isoform 1; Lymphocyte stimulatory factor 1; Macrophage fusion factor; Mast cell growth factor 2; MFF; MGC79402; Pitrakinra; TCGF2; IL4; interleukin 4; interleukin-4; B_cell stimulatory factor 1; BCGF 1; BSF1; IL-4; BCGF-1; il4/13b; interleukin 4/13B; IL2