The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.
interleukin 1 family, member 7 (zeta); Interleukin-1-related protein; FIL1Z; FIL1 zeta; IL-1 zeta; IL-1H4; IL-1RP1; IL-1X protein; IL1H4; IL1RP1; interleukin 1 family member 7; FIL1; interleukin 1, zeta; FIL1(ZETA); interleukin-1 family member 7; Interleukin-1 homolog 4; interleukin-1 superfamily z; Interleukin-1 zeta; IL-1X; IL-37; IL1F7; IL-1F7; interleukin-23; OTTHUMP00000162032; OTTHUMP00000162033; OTTHUMP00000162034; OTTHUMP00000162035; OTTHUMP00000162036; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); interleukin 37; IL37; IL-1H