The protein encoded by this gene is a member of the interleukin 1 cytokine family. Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding distinct isoforms have been reported.
2310043N20Rik; Family of interleukin 1 eta; FIL1; FIL1 (ETA); FIL1 eta; FIL1H; FILI-(ETA); IL 1F8; IL 1F8 (FIL1 eta; IL 1H2; IL-1 eta; IL-1F8; IL-1H2; IL1 ETA; IL1F8; IL1F8 (Canonical product IL 1F8a); IL1F8_HUMAN; IL1H2; IL36B; Interleukin 1 family, member 8; Interleukin 1 family, member 8 (eta); Interleukin 1 homolog 2; Interleukin 1 Superfamily e; Interleukin 36 beta; Interleukin-1 eta; Interleukin-1 family member 8; Interleukin-1 homolog 2; MGC126880; MGC126882; OTTMUSP00000012797; RP23-176J12.1