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il20

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Official Full Name
interleukin 20
Background
Human IL-20 or Interleukin-20, also known as Cytokine Zcyto10, is a 176 amino acid cytokine protein expressed from the IL20 gene located at locus 1q32 on chromosome 1. After initial synthesis of the protein, it undergoes proteolytic cleavage where the 24 residue signal sequence is cleaved, allowing for the proper folding and maturation of the IL-20 cytokine. Recent studies have determined that IL-20, belonging to the IL-10 family, may be involved in epidermal function and psoriasis via signal transduction through Signal Transducer and Activator of Transcription 3 (STAT3) in keratinocytes. It is expressed at very low levels in skin, trachea and other tissues.
Synonyms
UNQ852/PRO1801; IL-20; IL10D; ZCYTO10; cytokine Zcyto10; four alpha helix cytokine; interleukin-20; IL20; interleukin 20; IL 20; MGC96907

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