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il1rap

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Official Full Name
interleukin 1 receptor accessory protein
Background
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
Synonyms
IL1RAP; interleukin 1 receptor accessory protein; IL1R3; C3orf13; IL-1RAcP; IL-1R3; interleukin-1 receptor 3; interleukin-1 receptor accessory protein beta; OTTHUMP00000209487; OTTHUMP00000209488; OTTHUMP00000209489; OTTHUMP00000209490; OTTHUMP00000209491; OTTHUMP00000209492; IL-1 receptor accessory protein; OTTHUMP00000209493; FLJ37788; interleukin-1 receptor accessory protein; OTTHUMP00000209485; OTTHUMP00000209486; IL-1R-3; IL 1RAcP