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il18bp

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Official Full Name
interleukin 18 binding protein
Background
Interleukin 18 binding protein (IL-18 BP) is a secreted glycoprotein, which may function as a natural anti-inflammatory and immunosuppressive molecule neutralizing the effects of high IL18 levels during inflammation. It can prevent IL18 receptor binding and inhibits the production of IFN-gamma induced by IL18 in KG-1 cells. Aizawa et al (1999) have purified a mouse IL-18 binding protein and subsequently cloned the murine and human cDNA. Human and murine IL18BP share 60 % amino acid similarity.
Synonyms
IL18Bpa; interleukin-18-binding protein; IL-18BP; tadekinig-alfa; MC51L-53L-54L homolog gene product; I18BP_HUMAN; IL18 BP; IL18 BPa; Interleukin 18 binding protein; Tadekinig alfa; IL18BP; MC51L 53L 54L homolog gene product