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ikbip

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Official Full Name
IKBKB interacting protein
Background
IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. Its activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB. Activated IKK-β phosphorylates a protein called the inhibitor of NF-κB, IκB (IκBα), which binds NF-κB to inhibit its function. Phosphorylated IκB is degraded via the ubiquitination pathway, freeing NF-κB, and allowing its entry into the nucleus of the cell where it activates various genes involved in inflammation and other immune responses.
Synonyms
IKBIP; IKBKB interacting protein; inhibitor of nuclear factor kappa-B kinase-interacting protein; FLJ31051; I kappa B kinase interacting protein; IKIP; IKK interacting protein; IKK-interacting protein; IKBKB-interacting protein; i kappa-B kinase-interacti