This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an;IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor;acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the;plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate;transcriptional splice variants, encoding different isoforms, have been characterized.
IGFBP3; insulin-like growth factor binding protein 3; insulin-like growth factor-binding protein 3; acid stable subunit of the 140 K IGF complex; binding protein 29; binding protein 53; BP 53; growth hormone dependent binding protein; IBP3; IGF binding protein 3; IBP-3; IGFBP-3; IGF-binding protein 3; growth hormone-dependent binding protein; BP-53; zgc:91788