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igf2r

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Official Full Name
insulin-like growth factor 2 receptor
Background
The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
Synonyms
cation-independent mannose-6-phosphate receptor; M6PR; CI-MPR; MPR 300; M6P/IGF2R; IGF-II receptor; M6P/IGF2 receptor; OTTHUMP00000017536; CI Man-6-P receptor; 300 kDa mannose 6-phosphate receptor; MPR1; insulin-like growth factor II receptor; cation-independent mannose-6 phosphate receptor; CD222 antigen; MPRI; CD222; CIMPR; M6P-R; IGF2R; insulin-like growth factor 2 receptor; cation-independent mannose 6 phosphate receptor; si:ch211-214g8.2; cation-independent mannose 6-phosphate receptor