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icam-1

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Official Full Name
ICAM-1
Background
ICAM-1 (55 kDa) is a member of the immunoglobulin supergene family thatfunctions as a ligand for the Lymphocyte Function-Associated Antigen-1. It is asingle-chain glycoprotein that can be expressed on non-hematopoietic cells ofmany lineages. The role of ICAM-1 as a disease marker has been demonstrated fora number of different indications and pathological situations. ICAM-1 upregulation in allergic airway inflammation is responsible for therecruitment of activated leukocytes and the pathogenesis of allergic rhinitis.In lymphoproliferative disorders, ICAM-1 is related to the degree ofmalignancy.
Synonyms
ICAM-1