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iars

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Official Full Name
isoleucyl-tRNA synthetase
Background
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5 UTRs.
Synonyms
IARS; isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase, cytoplasmic; IARS1; ILRS; isoleucine tRNA ligase 1; cytoplasmic; FLJ20736; IleRS; IRS; Isoleucine tRNA ligase; Isoleucine tRNA synthetase; Isoleucyl tRNA synthetase; PRO0785; OTTHUMP00000021636; isoleucine--tRNA ligase; isoleucine tRNA ligase 1, cytoplasmic; fi46h05; zgc:63790; wu:fi46h05; isoleucine--tRNA ligase, cytoplasmic