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htra4

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Official Full Name
HtrA serine peptidase 4
Background
This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging.
Synonyms
HTRA4; HtrA serine peptidase 4; probable serine protease HTRA4; FLJ90724; High temperature requirement protean A4; HTRA 4; OTTHUMP00000225766