This gene encodes a member of the trypsin family of serine proteases. This protein is a secreted enzyme that is proposed to regulate the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. It has also been suggested to be a regulator of cell growth. Variations in the promoter region of this gene are the cause of susceptibility to age-related macular degeneration type 7.
HTRA1; HtrA serine peptidase 1; protease, serine, 11 (IGF binding) , PRSS11; serine protease HTRA1; HtrA; IGFBP5 protease; IGFBP5-protease; protease, serine, 11 (IGF binding); high-temperature requirement A serine peptidase 1; L56; ARMD7; ORF480; PRSS11