This gene encodes a major heat shock protein which functions as a chaperonin. Its structure consists of a heptameric ring which binds to another heat shock protein in order to form a symmetric, functional heterodimer which enhances protein folding in an ATP-dependent manner. This gene and its co-chaperonin, HSPD1, are arranged in a head-to-head orientation on chromosome 2. Naturally occurring read-through transcription occurs between this locus and the neighboring locus MOBKL3.
HSPE1; heat shock 10kDa protein 1 (chaperonin 10); heat shock 10kD protein 1 (chaperonin 10); 10 kDa heat shock protein, mitochondrial; CPN10; GROES; chaperonin 10; 10 kDa chaperonin; early-pregnancy factor; EPF; HSP10; heat shock protein 10; heat shock 10 protein 1; zgc:86747; heat shock 10 protein 1 (chaperonin 10)