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hrh1

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Official Full Name
histamine receptor H1
Background
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene was thought to be intronless until recently. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. Multiple alternatively spliced variants, encoding the same protein, have been identified.
Synonyms
HRH1; histamine receptor H1; histamine H1 receptor; H1R; HisH1; Histamine receptor subclass H1; HH1R; OTTHUMP00000160133; OTTHUMP00000207582; OTTHUMP00000207583; OTTHUMP00000209395; histamine H(1) receptor; histamine receptor, subclass H1; H1-R; 7 transmembrane receptor