In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila.
HOXA7; homeobox A7; homeo box A7 , HOX1, HOX1A; homeobox protein Hox-A7; ANTP; Homeobox protein HOX 1A; Homeobox protein Hox A7; Homeotic protein antennapedia; Hox 1.1; HOX1; HOX1A; homeo box A7; OTTHUMP00000217256; homeobox protein HOX-1A; homeobox protein Hox 1.1; HOX1.1; HOXA-7; homeodomain transcription factor HoxA-7