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homer3

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Official Full Name
homer homolog 3 (Drosophila)
Background
This gene encodes a member of the HOMER family of postsynaptic density scaffolding proteins that share a similar domain structure consisting of an N-terminal Enabled/vasodilator-stimulated phosphoprotein homology 1 domain which mediates protein-protein interactions, and a carboxy-terminal coiled-coil domain and two leucine zipper motifs that are involved in self-oligomerization. The encoded protein binds numerous other proteins including group I metabotropic glutamate receptors, inositol 1,4,5-trisphosphate receptors and amyloid precursor proteins and has been implicated in diverse biological functions such as neuronal signaling, T-cell activation and trafficking of amyloid beta peptides. Alternative splicing results in multiple transcript variants.
Synonyms
HOMER3; homer homolog 3 (Drosophila); homer protein homolog 3; HOMER 3; HOME3_HUMAN; Homer 3D protein; Homer neuronal immediate early gene 3; Homer-3; VESL3; Homer, neuronal immediate early gene, 3; zgc:55557

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