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Official Full Name
hes-related family bHLH transcription factor with YRPW motif 2
Background
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The encoded protein forms homo- or hetero-dimers that localize to the nucleus and interact with a histone deacetylase complex to repress transcription. Expression of this gene is induced by the Notch signal transduction pathway. Two similar and redundant genes in mouse are required for embryonic cardiovascular development, and are also implicated in neurogenesis and somitogenesis. Alternatively spliced transcript variants have been found, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Synonyms
HEY2; hes-related family bHLH transcription factor with YRPW motif 2; GRL; CHF1; HRT2; HERP1; HESR2; bHLHb32; GRIDLOCK; hairy/enhancer-of-split related with YRPW motif protein 2; HRT-2; hCHF1; hHRT2; HESR-2; protein gridlock homolog; HES-related repressor protein 1; HES-related repressor protein 2; hairy-related transcription factor 2; cardiovascular helix-loop-helix factor 1; class B basic helix-loop-helix protein 32; hairy and enhancer of split-related protein 2; cardiovascular basic helix-loop-helix factor 1; hairy/enhancer-of-split related with YRPW motif 2; MGC10720; GRL, CHF1, HRT2, HERP1, HESR2, bHLHb32, GRIDLOCK; zgc:136746; Herp2; protein gridlock