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herc3

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Official Full Name
HECT and RLD domain containing E3 ubiquitin protein ligase 3
Background
HERC3 belongs to the HERC family of ubiquitin ligases, all of which contain a HECT domain and at least 1 RCC1 (MIM;179710)-like domain (RLD). The 350-amino acid HECT domain is predicted to catalyze the formation of a thioester with;ubiquitin before transferring it to a substrate, and the RLD is predicted to act as a guanine nucleotide exchange;factor for small G proteins (Hochrainer et al., 2005 (PubMed 15676274)).
Synonyms
HERC3; HECT and RLD domain containing E3 ubiquitin protein ligase 3; hect domain and RLD 3; probable E3 ubiquitin-protein ligase HERC3; KIAA0032; HECT domain and RCC1-like domain-containing protein 3; si:ch73-190m4.3

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