Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. The protein encoded by this gene is a cytoplasmic enzyme which belongs to the class II family of aminoacyl-tRNA synthetases. The enzyme is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins. The gene is located in a head-to-head orientation with HARSL on chromosome five, where the homologous genes share a bidirectional promoter. The gene product is a frequent target of autoantibodies in the human autoimmune disease polymyositis/dermatomyositis.
HARS; histidyl-tRNA synthetase; histidyl-tRNA synthetase, cytoplasmic; histidine tRNA ligase 1; cytoplasmic; EC 18.104.22.168; FLJ20491; HisRS; histidine translase; Histidine tRNA ligase; Histidyl tRNA synthetase; HRS; Human histidyl tRNA synthetase homolog (HO3) mRNA complete cds; OTTHUMP00000159884; OTTHUMP00000223659; OTTHUMP00000223661; OTTHUMP00000223662; OTTHUMP00000223663; OTTHUMP00000223664; OTTHUMP00000224325; histidine-tRNA ligase; histidine--tRNA ligase; histidine tRN; histidine--tRNA ligase, cytoplasmic; USH3B; HARS, HRS, FLJ20491; zgc:92215; im:7136719