Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.
H3F3C; H3 histone, family 3C; histone H3.3C; H3.5; histone variant H3.5; H3-I; H3-V; H3-II; H3-IV; H3-VI; H3F3A; H3-III; H3-VII; H3-VIII; histone H3.2; histone H3 class I; H3 histone, family 3A; fj58b09; zgc:64222; wu:fj58b09