Official Full Name
granzyme H (cathepsin G-like 2, protein h-CCPX)
The protein encoded by this gene is a member of the granzyme family. Members of this family are highly conserved serine;proteases that eliminate transformed cells and virus-infected cells. This protein, which has chymotrypsin-like;activity, has a preference for bulky aromatic amino acids at the P1 position and for acidic residues at the P3 and;P4 positions. This protein is reported to be constitutively expressed in NK cells and may play a role in the;cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in;pathogen-infected cells. Alternative splicing results in multiple transcript variants that encode different protein;isoforms.
GZMH; granzyme H (cathepsin G-like 2, protein h-CCPX); CTSGL2; granzyme H; CCP X; CGL 2; CSP C; CTLA1; Cathepsin G like 2; CGL2; Cytotoxic serine protease C; Cytotoxic T lymphocyte associated serine esterase 1; Cytotoxic T lymphocyte proteinase; EC 3.4.21.-; Protein h CCPX; OTTHUMP00000178753; OTTHUMP00000245745; cathepsin G-like 2; cytotoxin serine protease-C; cytotoxic T-lymphocyte proteinase; cytotoxic T-lymphocyte-associated serine esterase 1; CCP-X; CGL-2; CSP-C; CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2