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gsr

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Official Full Name
glutathione reductase
Background
This gene encodes a member of the class-I pyridine nucleotide-disulfide oxidoreductase family. This enzyme is a homodimeric flavoprotein. It is a central enzyme of cellular antioxidant defense, and reduces oxidized glutathione disulfide (GSSG) to the sulfhydryl form GSH, which is an important cellular antioxidant. Rare mutations in this gene result in hereditary glutathione reductase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Aug 2010]
Synonyms
GSR; glutathione reductase; HEL-75; glutathione reductase, mitochondrial; GR; GRase; epididymis luminal protein 75; MGC78522; zgc:110010