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grsf1

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Official Full Name
G-rich RNA sequence binding factor 1
Background
G-rich sequence factor 1 (GRSF-1) is a cytoplasmic protein that binds RNAs containing the G-rich element. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. GRSF-1 is up-regulated with prostate cancer progression and down regulated by the differentiating agents phenylacetate and phenylbutyrate. The function of GRSF-1 is uncharacterized, but potential roles include mRNA transport, stabilization, or translation. It might react with G-rich containing mRNA of Bcl2 and Bax indicating a regulation role of GRSF-1 in metastatic prostate cancer.
Synonyms
GRSF1; G-rich RNA sequence binding factor 1; G-rich sequence factor 1; GRSF-1; FLJ13125; wu:fb62c04; zgc:153305