Official Full Name
Bombesin is a 14 amino acid peptide originally isolated from the skin of a frog. It has two known homologues in mammals called neuromedin B and gastrin releasing peptide. It works on the gastrointestinal tract neuroendocrine hormone and it stimulates gastrin release from G cells. It activates three different G-protein coupled receptors known as BBR1 2 & 3. It also activates these receptors in the brain. Together with cholecystokinin it is the second major source of negative feedback signals that stop eating behaviour. There are three different isoforms.
GRP; gastrin-releasing peptide; BN; GRP-10; proGRP; preproGRP; bombesin; neuromedin C; pre-progastrin releasing peptide; OTTHUMP00000163646; OTTHUMP00000235893; OTTHUMP00000235894; OTTHUMP00000235895; proventricular peptide; si:ch211-233a1.7; gastrin-releasing peptide-like