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grem2

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Official Full Name
gremlin 2, DAN family BMP antagonist
Background
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
Synonyms
GREM2; gremlin 2; gremlin 2, cysteine knot superfamily, homolog (Xenopus laevis); gremlin-2; CKTSF1B2; DAND3; FLJ21195; Prdc; protein related to DAN and cerberus; Cysteine knot superfamily 1 BMP antagonist 2; DAN domain family member 3; DAND 3; GREM 2; Gremlin 2 cysteine knot superfamily homolog; Gremlin2; cysteine knot superfamily 1, BMP antagonist 2; gremlin 2, cysteine knot superfamily, homolog; gremlin 2, DAN family BMP antagonist; zgc:112207; gremlin 2, cysteine knot superfamily; protein related to DAN and cerberus homolog