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gpr77

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Official Full Name
G protein-coupled receptor 77
Background
The anaphylatoxins C3a (see MIM 120700), C4a (see MIM 120810), and C5a are cationic fragments generated during the;complement cascade that participate in host defense. In the case of inappropriate complement activation,;anaphylatoxins may be involved in autoimmunity and sepsis. C5L2 is coexpressed with the C5a receptor, C5AR (C5R1; MIM;113995), on polymorphonuclear neutrophils and may modulate C5AR activity (Gerard et al., 2005 (PubMed;16204243)).
Synonyms
GPR77; G protein-coupled receptor 77; C5a anaphylatoxin chemotactic receptor C5L2; C5L2; G-protein coupled receptor 77; G protein-coupled receptor C5L2; GPF77