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gp6

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Official Full Name
glycoprotein VI (platelet)
Background
This gene encodes a platelet membrane glycoprotein of the immunoglobulin superfamily. The encoded protein is a receptor;for collagen and plays a critical role in collagen-induced platelet aggregation and thrombus formation. The encoded;protein forms a complex with the Fc receptor gamma-chain that initiates the platelet activation signaling cascade upon;collagen binding. Mutations in this gene are a cause of platelet-type bleeding disorder-11 (BDPLT11). Alternatively;spliced transcript variants encoding multiple isoforms have been observed for this gene.
Synonyms
GP6; glycoprotein VI (platelet); platelet glycoprotein VI; GPVI; Glycoprotein VI; GPIV; MGC138168; Platelet collagen receptor; Platelet glycoprotein VI precursor; glycoprotein 6; BDPLT11